NIH R01 · 2024
HSET as a racial disparity biomarker for TNBC patients
ABSTRACT! African ancestry is a risk factor for worse outcomes in triple-negative breast cancer (TNBC). Nevertheless, prognostic tools and treatment regimens are no different for African American (AA) than European American (EA) TNBC patients. Personalizing medicine for AA TNBC patients has been hindered by the fact that this population is highly admixed, so self-reported race often does not accurately reflect African genetic ancestry. There is also a dearth of studies that have analyzed tumor biomarkers and clinical outcomes using ancestry- genotyped TNBC specimens. Furthermore, few preclinical TNBC studies consider race in experimental design, and AA TNBC patients are markedly…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.