NIH R01 · 2025
The cellular molecular regulation of differing mechanisms of insulin resistance.
Project Summary Molecular & Genetic Problem: Lipid-induced hepatic insulin resistance is due to diacylglyceride (DAG)-induced protein kinase C epsilon (PKCε) activation leading to inhibition of insulin receptor tyrosine kinase [4, 5]. However, nonobese hyperandrogenic (HA) female mice displayed androgen-specific hepatic insulin resistance indicating a lipid-independent pathogenic mechanism [3]. Additionally, high fructose diets (HFrD) compared to high fat diets (HFD) display differing mechanisms of insulin resistance, where high fructose impairs glucokinase and glycogen synthase but high fat lowers p-AKT [6]. Ketohexokinase (KHK, also known as liver fructokinase) is required for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.