Andrews Lab

University of Florida

PATHOLOGY

Gainesville · United States

NIH-funded
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NIH R01 · 2024

Synthetic fentanyls adversely affect the blood-brain barrier and HIV replication in the context of neuroHIV

In the past two to three decades, there has been a surge in the use, abuse, and misuse of opioids. Among opioid users, Illicit fentanyl use has become widespread in the US. Moreover, synthetic fentanyls rapidly flood the illicit drug market due to their cheap manufacturing, enhanced potency, and chemical composition that evades toxicology screening. Furthermore, black-market drug makers create new fentanyl analogs to avoid classification as illegal, to get around policy restrictions. Although drugs of abuse and HIV are entwined epidemics, it is becoming clear that Fentanyl plays an alarming role in new outbreaks. Recent reports suggest that there's an elevated risk of acquiring HIV-1…

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