NIH R01 · 2024
Formation of the Drosophila salivary gland
The FoxA family of winged-helix DNA-binding transcription factors (TFs) play major roles in the development of many organs in vertebrate embryos. In some cases, they are proposed to be determinants of specific cell fates because they are expressed early and continuously in forming organs, and they are capable of what has been referred to as “pioneer” function – the ability to bind their target motifs even in closed chromatin, whereupon they can “open” that chromatin to make it accessible to other key tissue-specific “settler” TFs. Combined, the pioneer and settler TFs activate expression of the genes controlling tissue morphogenesis, specialization and homeostasis through their…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.