NIH R01 · 2024
Structural Studies of a T cell Specific Tyrosine Kinase
Project Summary T cell development, activation, and differentiation are all dependent on TCR signaling, along with important contributions from costimulatory and cytokine receptor pathways. Many lines of evidence indicate that variations in TCR signal strength have a major impact on the outcome of these processes. For mature CD8 T cells, TCR signal strength determines proliferative capacity and effector versus memory potential following infection. We assert that there is a growing need to develop a more comprehensive understanding of the pathways regulating distinct T cell functions and differentiation processes. Moreover, manipulation of T cell responses underlies many therapeutic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.