NIH R01 · 2025
Reprogramming myeloid cell metabolism to prevent cognitive aging and Alzheimer's Disease
REPROGRAMMING MYELOID CELL METABOLISM TO PREVENT COGNITIVE AGING AND ALZHEIMER’S DISEASE SUMMARY The brain is highly vulnerable to aging, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer’s disease (AD). Human genome-wide association studies demonstrate a dominant role for dysfunctional myeloid cells, which include brain microglia as well as peripheral monocytes/macrophages (Mo/Mph), in increasing risk of AD. Microglia lose their normal capacities to maintain immune homeostasis within the brain, provide trophic support to neurons, and clear misfolded proteins. Circulating factors in aged plasma influence microglial activation and are linked to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.