NIH R01 · 2024
Foundational Biology of Glaucoma GWAS Loci
Abstract Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. Damage from glaucoma is permanent and may cause irreversible blindness. Glaucoma is a major public health problem in the United States and worldwide, where it is the leading cause of irreversible blindness. Four classic risk factors have been identified for the most common type of glaucoma, primary open angle glaucoma (POAG): increasing age, race / ethnicity, family history, and increased intraocular pressure (IOP). Currently, all treatments for glaucoma slow or halt disease by targeting one risk factor, increased IOP. However, IOP-lowering therapies fail to prevent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.