NIH R01 · 2024
Quantitative genetic approaches to Candida albicans pathogenesis
ABSTRACT Candida albicans is a common fungal commensal and opportunistic pathogen occupying the skin, oral cavity, gastrointestinal tract, and genitourinary tract of its human host. Overgrowth of C. albicans within these host niches can lead to mucosal and systemic disease and typically relies on pathogenic processes such as the yeast-hyphal transition. Hyphae are capable of breaching host mucosal barriers through active penetration and endocytic uptake that both lead to host cell destruction and transmigration of C. albicans to deeper tissues. Thus, host epithelial cells serve a vital role in detecting C. albicans overgrowth and signaling to professional phagocytes to remove invasive…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.