Anderson Lab

Research focus

NIH R01 · 2024

Tuning peptide specifities for T cell tolerance in Type 1 diabetes

Project Summary/Abstract Type 1 Diabetes (T1D) is a classical T-cell mediated autoimmune disease and substantial data implicates insulin as a dominant autoantigen in T1D disease. In the NOD mouse model of T1D, notable studies have shown that mice lacking native insulin expression, but with an altered insulin sequence to maintain blood glucose levels, are completely protected from insulitis and diabetes. Growing evidence also indicates that insulin peptide binding and orientation within MHC Class II (peptide register) is important in determining the strength of interaction and recognition by autoreactive T cells. In collaboration with the Kappler lab, we have uncovered an unusual peptide…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.