NIH R01 · 2025
Epigenetic regulation of stress-potentiated ethanol drinking
Epigenetic Regulation of Stress-Potentiated Ethanol Drinking PROJECT SUMMARY/ABSTRACT A common mechanism that regulates both stress-sensitivity and alcohol use is epigenetic regulation of gene transcription. Of particular importance in substance-use disorders is G9a, a histone methyltransferase implicated in models of alcohol use disorder (AUD). G9a in the nucleus accumbens (NAc) regulates drinking, but its mechanisms are unknown. The long-term goal of this project is to elucidate the mechanisms that can lead to stress-potentiated drinking and to discover methods to block or reverse these changes. Because the dynorphin system plays a prominent role in stress and ethanol-related behaviors,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.