NIH R01 · 2024
Region-Specific, Inducible Axonal Tract-Tracing in the Brain
Project Summary/Abstract How neural circuits control complex behaviors is a fundamental problem in neuroscience. Optogenetic tools have transformed our ability to identify genetically marked neuronal subpopulations of interest (NSOIs), which serve as “points-of-entry” to behaviorally relevant circuits. However, a gap remains between the identification of such NSOIs, and the ability to identify and map their downstream target neurons (DTNs); identification of such DTNs is a crucial step in further tracing the circuit. To fill this gap, we will combine optogenetic stimulation of NSOIs with single-cell RNA sequencing (scRNAseq), automated immediate early gene (IEG) mapping, anatomical tracing…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.