NIH R01 · 2025
Project Summary Spinal cord injury (SCI) results in long-term functional impairments due to loss of cord tissue and limited regeneration. Human neural stem cell (hNSC) transplantation has exciting potential as a treatment for SCI, but the complex interactions between hNSC and the extrinsic microenvironment are poorly understood. The objective of this proposal is to address this gap in knowledge, enabling both optimization of therapeutic donor hNSC transplantation, as well as new insights into in vivo signaling/transcriptional networks, and the consequence of these networks for hNSC localization and fate after SCI. Critical to this is goal is elucidating mechanisms of immune-NSC signaling.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.