Andersen Lab

Research focus

NIH R01 · 2024

The Regulation and Function of the Ubiquitin-Sensing Kinase TNK1

PROJECT SUMMARY/ABSTRACT Alterations in kinase signaling underlie many of the most devastating human diseases, including degenerative disease, autoimmunity and cancer. Thus, not surprisingly, kinases are the second most targeted group of drug targets (next to G-protein coupled receptors). Yet despite their importance in disease, only about 8% of kinases are targets of FDA approved drugs and roughly a quarter of the 634 kinases in the human kinome is still considered ‘understudied’, leaving over 100 kinases untapped as potential therapeutic targets and without clear biological functions. This proposal focuses on TNK1, a poorly understood member of the ACK kinase family of non-receptor…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.