NIH R01 · 2025
Transcriptional Co-Regulators in Epidermis
PROJECT SUMMARY/ABSTRACT Although the epidermis is composed of morphologically distinct layers, single-cell RNA-seq experiments indicate that epidermal differentiation does not progress in discrete steps at a transcript level but is instead continuous and gradual. Consistent with this notion, we identified a large population of basal-to-spinous transition cells that reside in the basal and first spinous cell layers. These transition cells are found throughout the lifetime of the mouse and in the adult human palmoplantar and non-palmoplantar epidermis. Our hypothesis is that the presence of these transition cells does not reflect an ineffectiveness in switching from basal to spinous gene-…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.