Andermann Lab

Beth Israel Deaconess Medical Center

Boston · United States

NIH-funded
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NIH R01 · 2025

Roles of cortical neuromodulation and offline reactivation in memory consolidation of emotionally salient visual experiences

Summary What are the mechanisms by which we selectively remember sensory cues associated with salient outcomes? Salient sensory experiences activate distributed patterns of neurons in regions including sensory cortex, amygdala, and hippocampus. The linking of neural representations of cues and outcomes is believed to occur both online, during the sensory experiences, and offline, during joint reactivation of cue- and outcome-related patterns of neurons during subsequent quiet periods. Both the online and offline aspects of cue-outcome association learning have been posited to involve co-activation of neuromodulators that project to these distributed brain regions, which may facilitate…

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