NIH R01 · 2025
Promoting a reparative instead of a degenerative outcome from loading of fatigue-damaged tendons
Tendinopathies are common injuries that typically result from accumulation of sub-rupture fatigue damage. We have developed an in vivo model of sub-rupture fatigue damage accumulation using the rat patellar tendon to investigate the onset and pathogenesis of tendinopathy. We found that just one bout of fatigue loading results in collagen matrix damage and a 20% stiffness loss that is not recovered out to at least 10-weeks. We also found that running exercise leads to repair when initiated 2-weeks after onset of sub-rupture fatigue injury but promotes further degeneration when initiated 1-day after onset of injury, uniquely positioning us to determine the underlying mechanisms necessary to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.