NIH R01 · 2025
Pre and post-synaptic pathways underlying the stress response in the adrenal medulla
ABSTRACT The “fight-or-flight” response refers to the state of heightened physiological and mental arousal triggered by a physical threat, emotionally charged event, or metabolic disturbance. Although the precise reaction to each stressor may vary, all share some basic characteristics of sympathetic nervous system activation. Adrenomedullary chromaffin cells are core effectors of the sympathetic response in the periphery. When activated during stress, they discharge a cocktail of hormones into the suprarenal vein for circulation throughout the body. These hormones modulate cardiac, pulmonary, and metabolic functions in ways that favor survival or maintain internal conditions when they are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.