NIH R01 · 2025
Determinants of inception of inflammation in inflammatory bowel diseases
Project Summary Crohn’s disease (CD) and ulcerative colitis (UC) affect over 2 million individuals in the United States and are associated with considerable morbidity. Existing treatments achieve remission in fewer than 50% of patients. Further, despite achieving endoscopic remission, up to 30% of patients with CD or UC will relapse over the subsequent three years. Pathophysiologic mechanisms leading to relapse have not been well established. The central premise of our proposal is that despite endoscopic, there exists a local pro-inflammatory microbial milieu and transcriptional profile that favors disease relapse. We hypothesize that current clinical tools do not have sufficient resolution…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.