NIH R01 · 2025
New mechanisms governing skin tissue residency memory T cells
PROJECT SUMMARY Given the recent SARS CoV2 pandemic, and monkeypox outbreak, there is an urgent unmet need to understand immunity in our barrier tissues (e.g. skin, lung, and gut) where viruses are encountered. Tissue specific memory is needed for long-lived protective immunity, including immunization strategies that target infections and cancers of the tissue. T resident memory cells are long-lived memory populations generated by infections, cancers, and vaccines. Tissue resident memory T cells maintain long-term protective immunity to re-encountered pathogens (which include CoV2 and influenza in lung, and herpes, monkeypox, and smallpox in skin). Tissue resident memory T cells also survey…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.