NIH R01 · 2024
Circadian Organization and Disorder in Alzheimer's Disease
ABSTRACT With an aging population, the impact of Alzheimer's disease (AD) on public health continues to explode. Altered daily rhythms in physiology and behavior are prominent features of AD. These altered activity rhythms are difficult to treat, disrupting the lives of both patients and caregivers. Mounting evidence suggests that these changes are more than just symptoms. Altered rhythms may contribute to AD progression and development. Many important transcripts, proteins, and metabolites oscillate with a daily cycle. Understanding these rhythms, and their influence on AD, offers the potential to identify new therapies. The translation of circadian biology to Alzheimer's care is limited.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.