NIH R01 · 2025
Impaired Sleep as a Target for Intervention Following Acute Organophosphate Intoxication
Organophosphate cholinesterase inhibitors (OPs) were developed as agricultural insecticides and adapted to function as chemical weapons. OPs inhibit the acetylcholinesterase enzyme and acute intoxication can lead to a cholinergic crisis, status epilepticus (SE) and, for individuals who survive, the development of spontaneous recurrent seizures (SRS) and cognitive deficits. The current CounterACT PAR-24-030, supports research related to the 1) evaluation of the natural history to 2) elucidate mechanisms related to long-term effects of acute- intoxication, and in particular the development of SRS and cognitive dysfunction, that will 3) identify relevant biomarkers to predict long-term…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.