NIH R01 · 2025
ABSTRACT Erythropoiesis occurs at the erythroblastic island where the central macrophage (EBI M) supports proliferation and maturation of the surrounding erythroid cells. Alterations in EBI M contribute to the disordered erythropoiesis in various hematological diseases including polycythemia vera (PV) which is characterized by erythrocytosis due to V617F mutation in JAK2 (JAK2V/F). In this application, we propose to define the mechanisms by which EBI M support normal erythropoiesis in Aim 1 and to define the mechanisms by which JAK2V/F in EBI M contributes to pathogenesis of PV in Aim 2. Our overall hypothesis is that EBI M support normal erythropoiesis via Epor-Stat5…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.