NIH R01 · 2024
Mechanism and Significance of HMG Co-A Synthase 1 Degradation
Abstract The mevalonate pathway enzymes produce precursors of sterols and isoprenoids, essential metabolites for cell signaling and membrane biogenesis. As such, cells employ complex transcriptional, translational, and post- translational processes to regulate mevalonate production. Specifically, the ubiquitin proteasome system (UPS) tightly controls the mevalonate enzymes on the ER membrane, converging on the ER-associated degradation pathway. Importantly, increased levels of distinct sterol metabolites in the ER membrane cause proteolysis of specific enzymes, suggesting that the rate-liming enzyme in the mevalonate pathway can change based on the stimuli. While studies have focused on the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.