NIH R01 · 2025
Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging
SUMMARY To date nine hallmarks of the aging process have been described, which can be grouped into three major categories: primary hallmarks or cause of damage (genomic instability, telomere attrition, epigenetic alterations and loss of proteostasis), antagonist hallmarks or responses to damage (cellular senescence, mitochondrial dysfunction and deregulated nutrient sensing) and integrative hallmarks or manifestations of the aging phenotype (stem cell exhaustion and altered intercellular communication). Despite intensive research on each individual hallmark, little is known about their interconnectivity and the hierarchies governing those interactions. A limiting factor in these studies is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.