NIH R01 · 2024
Co-opting Lef-1 and miR-26b activities to regulate dental stem cells and their progeny
Project Summary Tissue specific regeneration requires the function of progenitor cells that can differentiate to repair diseased or injured tissues. Affected tissues can contain stem cells and their growth and patterning are controlled by transcription factors and signaling pathways. Stem cells derived from stem cell niches contribute to the regeneration of mature tissue types in many different organs, including the trachea, lungs and teeth, amongst others. These niches are formed in developing embryos, and must be maintained throughout life by symmetric cellular divisions that produce daughter pluripotent stem cells. Another equally important behavior of the cells in a stem cell niche is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.