NIH R01 · 2024
Glucocorticoid and SGK1 regulation of CFTR in the intestine: role in diarrhea
PROJECT SUMMARY Intestinal fluid secretion is a principal function of enterocytes and is mediated by the cystic fibrosis transmembrane conductance regulator anion channel, CFTR. Stress and CFTR are linked to common diarrheal diseases such as Irritable Bowel Syndrome (IBS-D) that affects 20% of the US population. CFTR is also linked to diarrhea due to genetic, inflammatory, common E. Coli infections, and other etiologies. But how stress exacerbates or leads to diarrhea is not understood. This proposal examines novel mechanisms that regulate CFTR in the intestine with the aim of advancing our knowledge of gut fluid secretion and developing new therapeutics. We have a special interest in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.