NIH R01 · 2024
Gender and sex dimorphism in age-related knee osteoarthritis
ABSTRACT As indicated by the 2019 Global Burden of Disease Study, although women, on average, have a longer lifespan than men, women typically experience worsened health outcomes as they age. Notably, postmenopausal women have a higher incidence of knee osteoarthritis (KOA) and present with more severe disease progression over time. However, it is still unclear whether these differences are genetic in nature, hormonal in nature, or a combination of the two. Here, we propose to investigate whether and how changes in the chondrocyte microenvironment—including soluble factors (Aim1) and extracellular matrix (ECM) stiffening (Aim2)—drive KOA pathogenesis in a sex-, gender- and age-dependent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.