NIH R01 · 2025
ABSTRACT Although studied for decades, the physiological changes in the basal ganglia thalamocortical (BGTC) circuit that underlie the development of motor signs of Parkinson’s disease (PD) remain under debate. Excessive synchronization and coherence in neural activity has been demonstrated within the internal segment of the globus pallidus (GPi) and between GPi - motor cortex (M1). However, the relationship of coherence within and across subcortical-cortical regions to severity of motor signs of PD, specifically bradykinesia, is not well understood. Deep brain stimulation (DBS) targeting the posterolateral sensorimotor region of GPi has been shown to be an effective location for reducing…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.