NIH R01 · 2024
Role of the brain-immune axis in neuropsychiatric disease
The study of brain-immune interactions has contributed to a paradigm shift in the understanding of the pathophysiology of mental disorders and has provided new insights into their prevention and treatment. Notably, the blood-brain barrier (BBB) functions to restrict interactions between the brain and periphery, limiting the influence of peripheral inflammation on the brain. However, increasing evidence indicates impairment of the BBB in conditions like autism and schizophrenia, which combined with the consistently elevated levels of the cytokines IL-6 and IL-1β, could potentially affect the ontology and outcome of neuropsychiatric disease. Thus, this proposal addresses the connectivity of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.