NIH R01 · 2024
Par-4 Regulation of Actomyosin Contractility as a Tumor Suppressive Mechanism in Breast Cancer
Project Summary/Abstract Tumor progression – including resistance to therapy, metastasis, and recurrence – is responsible for the majority of cancer deaths. Understanding how cancer cells survive treatment, spread to distant sites, persist as dormant residual cells, and eventually recur is essential to improving the treatment of this disease. The long-term goal of my research group is to identify the pathways that regulate these processes in order to prevent or treat tumor recurrence. To achieve, this we are using conditional genetically engineered mouse (GEM) models of breast cancer that allow for the mechanistic dissection of the processes of dormancy and recurrence. Using these models,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.