NIH R01 · 2024
Development of Synaptic Inputs on Spinal Interneurons
PROJECT SUMMARY (30-lines) Movement depends on patterned spinal cord motor output necessary for coordinated muscle actions. This in turn, depends on spinal interneuron microcircuits that modulate motoneuron recruitment and firing. The recent explosion of genetically-defined interneurons has revolutionized the study of spinal motor circuits promising a more comprehensive and complete dissection of these important networks. The work started by devising genetic strategies to identify, label, study and modify activity of large groups of interneurons defined by their derivation from specific progenitor domains. This is the approach mostly taken in previous years. Much new information was…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.