NIH R01 · 2024
Converting cytoskeletal forces into biochemical signals
PROJECT SUMMARY Cells perceive mechanical cues in their local environments, which must be converted into intracellular biochemical signals to modulate cellular physiology and control gene expression. There is increasing appreciation for mechanical signal transduction’s (“mechanotransduction”) critical role in development and its dysfunction in disease states such as cancer. However, in contrast to canonical signal transduction, cellular force sensing is poorly understood, hampering efforts to define mechanistically distinct mechanotransduction pathways, delineate their specific biological functions, and target them therapeutically. The actin cytoskeleton, a network of dynamic actin…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.