NIH R01 · 2025
Targeting Early Drivers of Prostate Cancer Lineage Plasticity
Lineage plasticity (LP)—most commonly exemplified by loss of androgen receptor (AR) signaling and switch from a luminal to an alternate differentiation program—is now recognized as a critical determinant of lethality. Most efforts in the field are focused on factors that promote terminal differentiation of specific LP subtypes such as neuroendocrine prostate cancer (NEPC). However, LP is a continuum, ranging from AR activity-low tumors with persistent AR expression but low AR signaling to those with alternate differentiation programs. Factors involved in the initiation and progression of LP have not been identified. The clarification of such factors is essential because there are no…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.