NIH R01 · 2024
Type III effector regulation of host signal transduction systems
Project Summary Bacterial Type 3 Secretion System (T3SS) “effector” proteins are the primary virulence factors that guide the progression of numerous Gram-negative bacterial infectious diseases. Recent studies have estimated that a single pathogen delivers up to 250 unique effector proteins directly into host cells. Collectively, these virulence factors suppress host innate immune responses and facilitate bacterial replication, dissemination, and disease progression. Therefore, determining how bacterial effector proteins control host intracellular communication pathways at the structural, biochemical, and cellular level is an ongoing challenge in infectious disease research. This proposal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.