NIH R01 · 2025
Microbial Metabolites Inhibiting Salmonella Carriage and Disease
ABSTRACT Diffusible signal factors (DSFs), long-chain fatty acids with a characteristic cis-2 unsaturation, are produced and used by several genera of gram-negative bacteria as quorum-sensing signals. We have found that the DSF cis-2 hexadecenoic acid (c2-HDA) is extremely potent in inhibiting expression of Salmonella functions necessary for colonization of the intestine and have found this compound to be present in the murine large intestine. As no mammalian source of fatty acids harboring a 2-cis unsaturation has been described, these findings strongly suggest that constituents of the gut microbiota produce and excrete DSFs that inhibit Salmonella virulence. We hypothesize that Salmonella…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.