Alter Lab

University of Pittsburgh at Pittsburgh

ANESTHESIOLOGY

Pittsburgh · United States

NIH-funded
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Research focus

NIH R01 · 2025

Leveraging inter-individual differences in walking pain and impairment to elucidate whole-person mechanisms of knee osteoarthritis

Project Summary/Abstract Knee osteoarthritis (OA) is a common and debilitating condition, affecting millions in the United States of America. From 1990 to 2020, OA ranked as the 14th highest cause of age-adjusted years lived with disability and is a serious disease due to disability, which increases mortality. Although the impact of knee OA on the population level is tremendous, there are significant inter-individual differences in pain and functional impairment. Weight- bearing, movement-evoked pain experienced during walking ranges from minimal to severe. Some patients maintain movement, experiencing a range of pain intensities, while others are immobilized due to pain. Factors…

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