NIH R01 · 2024
Mechanisms That Control Antigen Receptor Variable Region Exon Assembly
7. Project Summary/Abstract. During the past funding period, we discovered that the cohesin-mediated loop extrusion process involved in genome-wide modulation of chromosome architecture plays fundamental roles in V(D)J recombination and the generation of antibody diversity. In developing progenitor B cells, we found that cohesin-mediated loop extrusion linearly presents Ig heavy chain locus (Igh) VH, D, and JH gene segments to the RAG endonuclease for V(D)J recombination. Our preliminary data indicate that long-range V(D)J recombination in the Igk light chain locus may occur, at least in part, by a mechanistically distinct process from that of Igh. We propose 2 specific aims to elucidate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.