NIH R01 · 2025
Fast and slow prediction of stable and transient protein-protein interactions
Protein-protein interactions (PPIs) underpin processes ranging from transduction of signaling networks to maintenance of cellular structure. Identifying new human PPIs may uncover interactions targetable by PPI- modulating drugs, while identifying human-pathogen PPIs could shed light on processes driving infectious diseases. Many studies have experimentally mapped PPIs at scale, yet their cost and complexity, combined with the size of PPI space, have limited the degree to which PPIs can be fully mapped. In humans, only 20% of PPIs are estimated to be known while coverage of other organisms, including pathogens, is far lower. In silico methods can be faster and cheaper but have been beset by…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.