Almodovar Lab

Research focus

NIH R01 · 2025

Role of HIV gp120 and Nef in Transcriptome Dysregulation and Pulmonary Vascular Remodeling

PROJECT SUMMARY People living with HIV (PLWH) are at a significantly high risk of developing Pulmonary Hypertension (PH), which can lead to death by heart failure, even with the suppressive effects of antiretroviral therapy (ART). PH is characterized by phenotypic changes in endothelial cells that result in increased pulmonary artery pressures and right ventricular hypertrophy. However, the underlying mechanism of how HIV contributes to the development of HIV-PH is still not fully understood. Our team has previously identified an association between specific HIV polymorphisms and the susceptibility to HIV-PH in patients. This proposal focuses on increasing the knowledge of how the pulmonary…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.