NIH R01 · 2024
Stem Cell Dysfunction in Aged Skeletal Muscle
Abstract One of the greatest mysteries in ageing biology is to understand why many tissues and organs in our body, including skeletal muscle, decline in function as we get older? Recent studies suggest that the inability of muscle stem cells (MuSCs) to turn on the repair program after trauma is a major factor leading to the loss of muscle mass and strength observed in the elderly. However, given that the signals driving MuSCs into the regenerative state remains a mystery even in young adults, we are left with virtually no therapeutic options for boosting the repair potential of aging MuSCs in the clinic. To address this unmet need, my laboratory recently discovered a new “Super-Healing”…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.