NIH R01 · 2024
Osteocytic mechanisms required for spatiotemporal control of bone quality
SUMMARY Bone fragility cannot be explained by bone mineral density (BMD) alone and also results from defects in the material properties of the bone matrix, termed bone quality (BQ). Since diagnostics or therapies to identify or treat poor BQ do not exist, understanding the control of BQ is a clinical imperative for treating skeletal fragility. This proposal aims to uncover these fundamental biological and material mechanisms controlling BQ by focusing on the beneficial effects of exercise on BQ. Using a mouse exercise model that can reliably induce and rigorously monitor dynamic changes in local BQ, Dr. Kohn found that exercise-dependent control of BQ strengthens bone independently of BMD.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.