NIH R01 · 2025
Enabling systemic delivery of europium-containing contrast agents for magnetic resonance imaging
The ability to image the presence or absence of oxygen is of paramount importance to the study of biochemistry, medicine, and multiple diseases. Hypoxia is linked to a variety of diseases including kidney disease; hepatic and neurological toxicities; and the progression, proliferation, and therapy resistance of many cancers, making hypoxia an important diagnostic and therapeutic target. This proposal describes plans to study a new class of phosphonate-containing complexes of EuII that are compatible with systemic delivery, where the lack of systemic delivery is the largest obstacles to the widespread use of EuII for imaging hypoxia in multiple diseases. Specifically, we propose to address…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.