NIH R01 · 2024
Complex glycoconjugates play a pivotal role in bacterial survival, colonization, and virulence, and contribute to the interactions between symbiotic and pathogenic bacteria and their human hosts. Assembly of these macromolecules is initiated on the cytoplasmic face of cell membranes, catalyzed by polyprenol phosphate (PrenP) phosphoglycosyl transferases (PGTs). PGTs transfer a C1’-phosphosugar from a soluble nucleoside diphosphate-sugar to a PrenP acceptor, yielding a membrane-bound polyprenol diphosphosugar. Our studies focus on the exclusively prokaryotic PGT superfamily with a monotopic membrane topology (monoPGTs). Our work has previously led to the mechanistic and structural…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.