NIH R01 · 2024
Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironment
PROJECT SUMMARY/ABSTRACT Pancreatic cancer is a deadly human malignancy, with a five-year survival rate of 11%. Further, the incidence of pancreatic cancer is rising and is projected to be the second-leading cause of cancer-related death in the United States by 2030. The increasing occurrence of this disease, combined with the lack of effective treatments, creates an urgent need to better understand the factors that contribute to the progression of pancreatic cancer, and to develop improved therapies that will tangibly benefit human health. One pathway that has been implicated in pancreatic cancer for nearly twenty years is the Hedgehog (HH) signaling pathway. Initial work demonstrated that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.