NIH R01 · 2025
PROJECT SUMMARY / ABSTRACT Engineering advances applied to miniaturized analytical instrumentation will be employed to improve sensitivity and throughput of thin-layer chromatography enabling single-cell analyses of the biochemical activity of lipid modifying enzymes in the cells of patients. By utilizing micro- and nanofabrication techniques, the proposed work will develop a novel ultra-miniaturized device termed picoliter thin-layer chromatography (pTLC) suitable for assays at high throughput and sensitivity. A multidisciplinary collaboration encompassing bioengineering, chemistry and oncology will develop the pTLC chip and integrate its supporting hardware to create an easy-to-use…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.