Allayee Lab

Research focus

NIH R01 · 2024

Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease

PROJECT SUMMARY Myocardial infarction (MI) and coronary artery disease (CAD) are the leading causes of death in Western societies. Individuals with CAD are typically asymptomatic, with the first manifestations often being major adverse cardiac events (MACE), such as MI, stroke, or sudden death due to the rupture of an atherosclerotic plaque. However, despite the clinical significance of these thrombotic events, our understanding of the genetic and molecular basis of MI remains incomplete. Furthermore, even though most patients with MI have CAD, not all patients with CAD develop MI. This observation suggests that some of the mechanisms that predispose to MI may be distinct from those that…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.