NIH R01 · 2024
The impact of stress neurohormones on health and aging
Project Summary The major goal of this project is to elucidate how stress negatively impacts health and accelerates aging. In both animals and humans, repeated activation of the fight or flight response increases disease susceptibility and reduces lifespan. How it does so is not well understood. In mammals, stress disorder symptoms are associated with high levels of stress hormones such as adrenaline, which are released by the sympathetic nervous system in response to acute stress. However, the complexity of the nervous system and the multifaceted stress response in mammals makes the study of how the flight response impairs health and accelerates aging an exceedingly difficult task. We…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.