NIH R01 · 2024
Predicting Fracture Risk in Patients Treated with Radiotherapy for Spinal Metastatic Disease
Project Summary/Abstract We seek to validate a quantitative method to predict the risk of pathologic vertebral fracture (PVF) in cancer patients treated with radiotherapy for metastatic spine disease before the onset of these complications. Vertebral bone is the most frequent site of skeletal metastasis. Radiation therapy aims to palliate pain and reduce the risk of PVF. However, PVF are a common complication afflicting up to 39% of patients within 6 months after-radiotherapy. Clinical guidelines for estimating fracture risk remain subjective and suffer from low specificity and sensitivity. Improved prediction of PVF risk would facilitate selection of whether, how, and when to intervene…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.