NIH R01 · 2024
Blood DNA Methylation Biomarkers of Alzheimer's Disease
Project Summary Recent array-based epigenome-wide association studies (EWAS) of brain tissue report differential DNA methylation in known and newly recognized late-onset sporadic Alzheimer’s disease (LOAD) genes, thereby underscoring the utility of EWAS in disclosing novel genes and pathways associated with LOAD pathogenesis. As an alternative to the study of samples from donor brains, investigation of DNA methylation in accessible peripheral tissues offers the opportunity to improve LOAD diagnosis and prognosis. Recently, we’ve identified differentially methylated positions (DMPs) in blood that distinguish men and women with and without LOAD at 477 of 769,190 loci in a plurality of genes.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.