Aliabouzar Lab

Research focus

NIH R01 · 2025

Real-Time, Non-Invasive Thrombus Characterization using Ultrasound Responsive Nanodroplets

ABSTRACT Thrombosis is a leading cause of morbidity and mortality worldwide, associated with several serious health complications including pulmonary hypertension, cardiovascular disease, and death. As thrombi mature, their structural and mechanical properties change, becoming mechanically less compliant due to fibrin crosslinking and gradual collagen deposition. The evolving mechanical properties of thrombi over time necessitates a dynamic and adaptable approach for timely diagnosis and treatment management. However, current diagnostic methods are primarily for detection of thrombi and fail to provide critical information about thrombus age and mechanical characteristics. This limitation…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.